Yes. Just connect a reader to the Wiegand terminal of MD-08, and connect the RS-232 of MD-08 to the computer. The enrollment of cards can be done by AxTrax/AxTraxNG.
AxTrax: Cards -> New -> MD-08 tab -> Select COM port
AxTraxNG: Users -> Cards -> Press the button “Insert card by MD-08” on the toolbar -> Select COM port